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<h1 id="firstHeading" class="firstHeading mw-first-heading"><span class="mw-page-title-main">Integrin α-V</span></h1>
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<div id="mw-content-text" class="mw-body-content mw-content-ltr" lang="de" dir="ltr"><div class="mw-content-ltr mw-parser-output" lang="de" dir="ltr"><table class="wikitable hintergrundfarbe-basis infobox float-right" id="Vorlage_Infobox_Protein_Integrin_alpha-V" style="font-size:90%; margin-top:0; width:350px;" summary="Infobox Protein">
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<th colspan="3" style="background:#90EE90; color:#202122;">Integrin alpha-V
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<td colspan="3"><span typeof="mw:File"></span>
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<td colspan="3" class="hintergrundfarbe1" style="text-align:center; font-size:smaller; font-weight:bold;">nach <a href="Protein_Data_Bank" title="Protein Data Bank">PDB</a> <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/1JV2">1JV2</a>
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<td>Andere Namen
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<p>Vitronectin receptor subunit alpha, CD antigen: CD51
</p>
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<td colspan="3" class="hintergrundfarbe1" style="font-size:smaller;">
<p>Vorhandene Strukturdaten: <a href="Protein_Data_Bank" title="Protein Data Bank">PDB</a> <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/1L5G">1L5G</a>, <a href="Protein_Data_Bank" title="Protein Data Bank">PDB</a> <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/1M1X">1M1X</a>
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<th colspan="3" style="background:#90EE90; color:#202122;;">Eigenschaften des menschlichen Proteins
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<td><a href="Molare_Masse" title="Molare Masse">Masse</a>/Länge <a href="Prim%C3%A4rstruktur" title="Primärstruktur">Primärstruktur</a>
</td>
<td colspan="2" style="text-align:center;">1.048 <a href="Aminos%C3%A4uren" title="Aminosäuren">Aminosäuren</a>, 116.038 <a href="Atomare_Masseneinheit" title="Atomare Masseneinheit">Da</a>
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<th colspan="3" style="background:#90EE90; color:#202122;">Bezeichner
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<td><a href="Human_Genome_Organisation" title="Human Genome Organisation">Gen-Name</a>
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<td colspan="2" class="" style="text-align:center;"><i><a rel="nofollow" class="external text" href="https://www.genenames.org/tools/search/#!/all?query=6150">ITGAV</a></i>
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<td>Externe IDs
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<ul><li><a href="GeneCards" title="GeneCards">GeneCards</a>: <a rel="nofollow" class="external text" href="http://www.genecards.org/cgi-bin/carddisp.pl?gene=ITGAV">ITGAV</a></li>
<li><a href="Online_Mendelian_Inheritance_in_Man" title="Online Mendelian Inheritance in Man">OMIM</a>: <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/omim/193210">193210</a></li>
<li><a href="UniProt" title="UniProt">UniProt</a> <a rel="nofollow" class="external text" href="https://www.uniprot.org/uniprotkb/P06756">P06756</a></li></ul>
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<th colspan="3" style="background:#90EE90; color:#202122;">Vorkommen
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<td style="background:#C3FDB8; color:#202122;">Homologie-Familie
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<td colspan="2" style="text-align:center;"><a rel="nofollow" class="external text" href="http://hogenom.univ-lyon1.fr/query_sequence?seq=P06756">Hovergen</a>
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<td colspan="3" style="background:#90EE90; color:#202122; text-align:center;"><a href="Homologie_(Genetik)#Homologie_zwischen_verdoppelten_oder_fremden_Genen" title="Homologie (Genetik)">Orthologe</a> (Mensch)
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<td style="background:#C3FDB8; color:#202122;"><a href="Entrez_Gene" title="Entrez Gene">Entrez</a>
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<td colspan="2"><span class=""><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=retrieve&dopt=default&list_uids=3685&rn=1">3685</a></span>
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<td style="background:#C3FDB8; color:#202122;"><a href="Ensembl" title="Ensembl">Ensembl</a>
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<td colspan="2"><span class=""><small><small><a rel="nofollow" class="external text" href="http://www.ensembl.org/Homo_sapiens/geneview?gene=ENSG00000138448;db=core">ENSG00000138448</a></small></small></span>
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<td style="background:#C3FDB8; color:#202122;"><a href="UniProt" title="UniProt">UniProt</a>
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<td colspan="2"><a rel="nofollow" class="external text" href="https://www.uniprot.org/uniprotkb/P06756">P06756</a>
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<td style="background:#C3FDB8; color:#202122;"><a href="National_Center_for_Biotechnology_Information" title="National Center for Biotechnology Information">Refseq</a> (mRNA)
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<td colspan="2"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_001144999.2">NM_001144999.2</a>
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<td style="background:#C3FDB8; color:#202122;"><a href="National_Center_for_Biotechnology_Information" title="National Center for Biotechnology Information">Refseq</a> (Protein)
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<td colspan="2"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_001138471.1">NP_001138471.1</a>
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<td style="background:#C3FDB8; color:#202122;"><a href="PubMed" title="PubMed">PubMed</a>-Suche
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<td colspan="2"><span class=""><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Link&LinkName=gene_pubmed&from_uid=3685">3685</a></span>
<p><span class="editoronly" style="display:none;"></span>
</p>
</td></tr></tbody></table><p><span class="editoronly" style="display:none;"></span>
</p><p><b>Integrin α-V</b> (CD51) ist ein <a href="Oberfl%C3%A4chenprotein" class="mw-redirect" title="Oberflächenprotein">Oberflächenprotein</a> aus der Gruppe der <a href="Integrine" title="Integrine">Integrine</a>.
</p>
<div class="mw-heading mw-heading2"><h2 id="Eigenschaften">Eigenschaften</h2></div>
<p>Integrin α-V ist ein <a href="Zelladh%C3%A4sionsmolek%C3%BCl" title="Zelladhäsionsmolekül">Zelladhäsionsmolekül</a> und bindet an die <a href="RGD-Sequenz" title="RGD-Sequenz">RGD-Sequenz</a> sowie <a href="Vitronectin" title="Vitronectin">Vitronectin</a>, Cytotactin, <a href="Fibronectin" class="mw-redirect" title="Fibronectin">Fibronectin</a>, <a href="Fibrinogen" title="Fibrinogen">Fibrinogen</a>, <a href="Laminin" class="mw-redirect" title="Laminin">Laminin</a>, Matrix-Metalloproteinase-2, <a href="Osteopontin" title="Osteopontin">Osteopontin</a>, Osteomodulin, <a href="Prothrombin" class="mw-redirect" title="Prothrombin">Prothrombin</a>, <a href="Thrombospondin" title="Thrombospondin">Thrombospondin</a> und den <a href="Von-Willebrand-Faktor" title="Von-Willebrand-Faktor">Von-Willebrand-Faktor</a>. Es ist <a href="Glykosyliert" class="mw-redirect" title="Glykosyliert">glykosyliert</a>. Integrin α-V bildet einen <a href="Heterodimer" class="mw-redirect" title="Heterodimer">heterodimeren</a> <a href="Rezeptor_(Biochemie)" title="Rezeptor (Biochemie)">Rezeptor</a> mit <a href="Integrin_beta-3" class="mw-redirect" title="Integrin beta-3">Integrin beta-3</a> für Fractalkin, FGF-1, <a href="IGF-1" class="mw-redirect" title="IGF-1">IGF-1</a>, und NRG1. Weiterhin bindet es PLA2G2A an einer anderen Bindungsstelle, wodurch die <a href="Affinit%C3%A4t_(Biochemie)" title="Affinität (Biochemie)">Affinität</a> der Bindung anderer <a href="Ligand_(Biochemie)" title="Ligand (Biochemie)">Liganden</a> erhöht wird. Der Rezeptor aus Integrin alpha-V und Integrin beta-3 sowie der Komplex aus Integrin alpha-V und Integrin beta-6 binden Fibrillin-1 und sind dadurch an der <a href="Zelladh%C3%A4sion" title="Zelladhäsion">Zelladhäsion</a> beteiligt.
</p><p>Das <a href="Adenovirus" class="mw-redirect" title="Adenovirus">Adenovirus</a> des Typs C verwendet den Komplex aus Integrin α-V und Integrin beta-5 als Rezeptor. Coxsackieviren der Typen A9 und B1 verwenden den Komplex aus Integrin α-V und entweder Integrin beta-3 oder Integrin beta-5 als Rezeptor. Das <a href="HHV-8" class="mw-redirect" title="HHV-8">HHV-8</a>, das <a href="West-Nil-Virus" title="West-Nil-Virus">West-Nil-Virus</a> und das humane Parechovirus 1 verwenden den Komplex aus Integrin α-V und Integrin beta-3 als Rezeptor.
</p><p>Die Antikörper Abituzumab und Intetumumab binden an Integrin α-V.<sup id="cite_ref-DOI10.1093/annonc/mdu474_1-0" class="reference"><a href="#cite_note-DOI10.1093/annonc/mdu474-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup>
</p>
<div class="mw-heading mw-heading2"><h2 id="Weblinks">Weblinks</h2></div>
<ul><li><a href="Medical_Subject_Headings" title="Medical Subject Headings">MeSH</a> <i><a rel="nofollow" class="external text" href="https://meshb.nlm.nih.gov/search?searchMethod=FullWord&searchInField=termDescriptor&sort=&size=20&searchType=exactMatch&q=Integrin+alpha-V">Integrin α-V</a></i></li></ul>
<div class="mw-heading mw-heading2"><h2 id="Einzelnachweise">Einzelnachweise</h2></div>
<ol class="references">
<li id="cite_note-DOI10.1093/annonc/mdu474-1"><span class="mw-cite-backlink"><a href="#cite_ref-DOI10.1093/annonc/mdu474_1-0">↑</a></span> <span class="reference-text">E. Élez, I. Kocáková, T. Höhler, U. M. Martens, C. Bokemeyer, E. Van Cutsem, B. Melichar, M. Smakal, T. Csőszi, E. Topuzov, R. Orlova, S. Tjulandin, F. Rivera, J. Straub, R. Bruns, S. Quaratino, J. Tabernero: <i> Abituzumab combined with cetuximab plus irinotecan versus cetuximab plus irinotecan alone for patients with wild-type metastatic colorectal cancer: the randomised phase I/II POSEIDON trial .</i> In: <i>Annals of Oncology.</i> 26, 2014, S. 132, <a href="Digital_Object_Identifier" title="Digital Object Identifier">doi</a>:<span class="uri-handle" style="white-space:nowrap"><a rel="nofollow" class="external text" href="https://doi.org/10.1093/annonc%2Fmdu474">10.1093/annonc/mdu474</a></span>.</span>
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